Associate Scientist II, In Vivo Discovery - 2514

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world.  Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.  

Why Choose Editas?

At Editas Medicine, we’re a team of courageous problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!

Decoding The Role:

As an Associate Scientist II, In Vivo Discovery, you’ll be a vital contributor to our mission and our success. The Preclinical Discovery team at Editas is focused on developing novel gene editing strategies for in vivo gene editing programs and is looking to add a highly talented and motivated candidate to help develop delivery strategies for gene editing machinery into target cells in vivo. This individual will help the development of novel cellular targeting strategies and implement these technologies to treat therapeutic indications with significant unmet medical needs. In addition, they will provide molecular biology and cellular assay development support to Editas’ in vitro and in vivo pre-clinical studies. With a strong foundation in cellular and in vivo biology, this person will work within cross-functional teams including Advanced Technologies, Human Genetics and Genomics, Platform Technology, and Translational Science in development and commercialization of in vivo gene editing drug products.

Characterizing Your Impact:

As the Associate Scientist II, In Vivo Discovery, you will:

• Development and optimization of molecular assays for evaluating editing outcomes of CRISPR-based therapeutics in an in vivo context. 
• Work with primary cells and cell lines.
• Develop and perform in vitro cell-based assays supporting the pharmacology of CRISPR-based therapeutics.
• Support in vivo studies for evaluation of LNP targeting and biodistribution.
• Maintain an electronic lab notebook in a timely fashion.
• Analyze and present data within the organization.

Requirements

The Ideal Transcript:

To thrive in this role, you’ll need:

• BS/MS in Biology or related discipline and 6+/4+ years of hands-on research experience in academic and/or pharmaceutical/biotech environment.
• Skilled in molecular assays including ddPCR, Jess capillary electrophoresis or traditional SDS-PAGE/western blotting, flow cytometry, and plate-based assays including ELISA. Demonstrated knowledge in assay development and optimization.
• Cell culture experience and experience with cell-based assays.

Fundamentals That Set You Apart

• Animal handling, dosing and tissue collection experience.
• Hepatocyte cell culture experience is a plus.
• iPSC generation and differentiation.
• Self-motivated, result-driven with excellent attention to details and ability to independently execute protocols to drive assignments to completion.
• Team oriented and excel in a fast-paced and dynamic team environment.
• Excellent oral and written communication skills.
• Well-organized and excellent at multi-tasking.
• Ability to form hypotheses, think critically, extract conclusions from datasets to inform future studies.

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.